Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase.
Cancer risk
Inflammation
Metabolic syndrome
Oncogenesis
Oxidative stress
Xanthine oxidoreductase
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
09
11
2018
revised:
29
11
2018
accepted:
06
12
2018
pubmed:
24
12
2018
medline:
4
4
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders. XOR can play a role in the pathogenesis of both metabolic syndrome and cancer through the inflammatory response and the oxidative stress elicited by the products of its activity. The reactive oxygen and nitrogen species and the uric acid derived from XOR concur to the development of hypertension, dyslipidemia and insulin resistance and participate in both cell transformation and proliferation, as well as in the progression and metastasis process. Despite the availability of different drugs to inhibit in vivo XOR activity, the complexity of XOR inhibition effects should be carefully considered before clinical application, save in the case of symptomatic hyperuricemia.
Identifiants
pubmed: 30576922
pii: S2213-2317(18)31052-8
doi: 10.1016/j.redox.2018.101070
pmc: PMC6302121
pii:
doi:
Substances chimiques
Xanthine Dehydrogenase
EC 1.17.1.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101070Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
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