Early childhood family instability and immune system dysregulation in adolescence.
Adolescent health
Childhood stress
Epstein-Barr virus
Virus reactivation
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
14
09
2018
revised:
11
12
2018
accepted:
11
12
2018
pubmed:
24
12
2018
medline:
18
3
2020
entrez:
23
12
2018
Statut:
ppublish
Résumé
Exposure to stress is one way in which social disadvantages during childhood may alter biological and psychological systems with long-term consequences. Family social and economic conditions are critical for early childhood development and exposure to difficult family conditions may have lasting physiological effects. However, there is little research linking early childhood conditions with physiological indicators of stress and system dysregulation in adolescence. In this study, we assess how family social and economic instability that occurred in early childhood (birth to age 5) is associated with immune system dysregulation in adolescence, as indicated by DNA shedding of the Epstein-Barr virus (EBV). We utilize a biomarker of EBV obtained through saliva, a non-invasive method of collecting immune-system biomarkers, in 674 adolescents 11-17 years old. Multivariable regression results indicated that experiences of moving into a new parent/caregiver household or moving in with a grandparent during early childhood was associated with an estimated 100% increase in EBV DNA shedding among prior EBV-infected adolescents. Other measures of early childhood family instability, total number of family structure changes and economic insecurity, were marginally significant. Contemporaneous family conditions were not associated with adolescents' EBV DNA shedding.
Identifiants
pubmed: 30579236
pii: S0306-4530(18)30939-9
doi: 10.1016/j.psyneuen.2018.12.014
pmc: PMC6689237
mid: NIHMS1517103
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-195Subventions
Organisme : NICHD NIH HHS
ID : K01 HD077063
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD058484
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA032371
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA034960
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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