Role of meprin metalloproteinases in cytokine processing and inflammation.
CCL2
IL-18
IL-1β
IL-6
IL-6R
Inflammation
Meprin A
Meprin α
Meprin β
Metalloproteinase
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
05
10
2018
revised:
16
11
2018
accepted:
25
11
2018
pubmed:
24
12
2018
medline:
27
3
2020
entrez:
24
12
2018
Statut:
ppublish
Résumé
Meprin metalloendopeptidases, comprising α and β isoforms, are widely expressed in mammalian cells and organs including kidney, intestines, lungs, skin, and bladder, and in a variety of immune cells and cancer cells. Meprins proteolytically process many inflammatory mediators, including cytokines, chemokines, and other bioactive proteins and peptides that control the function of immune cells. The knowledge of meprin-mediated processing of inflammatory mediators and other target substrates provides a pathophysiologic link for the involvement of meprins in the pathogenesis of many inflammatory disorders. Meprins are now known to play important roles in inflammatory diseases including acute kidney injury, sepsis, urinary tract infections, bladder inflammation, and inflammatory bowel disease. The proteolysis of epithelial and endothelial barriers including cell junctional proteins by meprins promotes leukocyte influx into areas of tissue damage to result in inflammation. Meprins degrade extracellular matrix proteins; this ability of meprins is implicated in the cell migration of leukocytes and the invasion of tumor cells that express meprins. Proteolytic processing and maturation of procollagens provides evidence that meprins are involved in collagen maturation and deposition in the fibrotic processes involved in the formation of keloids and hypertrophic scars and lung fibrosis. This review highlights recent progress in understanding the role of meprins in inflammatory disorders in both human and mouse models.
Identifiants
pubmed: 30580156
pii: S1043-4666(18)30474-5
doi: 10.1016/j.cyto.2018.11.032
pmc: PMC6414266
mid: NIHMS1517224
pii:
doi:
Substances chimiques
Cytokines
0
Extracellular Matrix Proteins
0
Metalloproteases
EC 3.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-25Subventions
Organisme : BLRD VA
ID : I01 BX000444
Pays : United States
Organisme : BLRD VA
ID : I01 BX000538
Pays : United States
Organisme : BLRD VA
ID : I01 BX000828
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK081690
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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