Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy.
Aged
Biomarkers
/ metabolism
Blood Glucose
/ metabolism
Computed Tomography Angiography
Coronary Angiography
/ methods
Coronary Artery Disease
/ blood
Coronary Vessels
/ diagnostic imaging
Diabetes Mellitus
/ blood
Disease Progression
Female
Humans
Longitudinal Studies
Male
Middle Aged
Plaque, Atherosclerotic
Prediabetic State
/ blood
Predictive Value of Tests
Prognosis
Registries
Risk Factors
Time Factors
Coronary atherosclerosis
Coronary computed tomography angiography
Pre-diabetes
Journal
Journal of cardiovascular computed tomography
ISSN: 1876-861X
Titre abrégé: J Cardiovasc Comput Tomogr
Pays: United States
ID NLM: 101308347
Informations de publication
Date de publication:
Historique:
received:
11
06
2018
revised:
29
11
2018
accepted:
16
12
2018
pubmed:
26
12
2018
medline:
14
6
2019
entrez:
25
12
2018
Statut:
ppublish
Résumé
Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. ClinicalTrials.govNCT02803411.
Sections du résumé
BACKGROUND
BACKGROUND
Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA).
METHODS
METHODS
A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM).
RESULTS
RESULTS
During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm
CONCLUSION
CONCLUSIONS
DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors.
CLINICAL TRIAL REGISTRATION
BACKGROUND
ClinicalTrials.govNCT02803411.
Identifiants
pubmed: 30580992
pii: S1934-5925(18)30181-3
doi: 10.1016/j.jcct.2018.12.002
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Banques de données
ClinicalTrials.gov
['NCT02803411']
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-147Informations de copyright
Copyright © 2018. Published by Elsevier Inc.