The added value of cardiopulmonary exercise testing in the follow-up of pulmonary arterial hypertension.
cardiopulmonary exercise test
clinical worsening
oxygen uptake
pulmonary arterial hypertension
validation
Journal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN: 1557-3117
Titre abrégé: J Heart Lung Transplant
Pays: United States
ID NLM: 9102703
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
13
02
2018
revised:
25
11
2018
accepted:
30
11
2018
pubmed:
26
12
2018
medline:
1
9
2020
entrez:
25
12
2018
Statut:
ppublish
Résumé
The added value of cardiopulmonary exercise testing (CPET) in the follow-up of patients with stable pulmonary arterial hypertension (PAH) remains undefined. Idiopathic, heritable, and drug-induced PAH patients free from clinical worsening (CW) after 1 year of treatment were enrolled in derivation (n = 80) and validation (n = 80) cohorts at an interval of 6 years and followed for 3 years. Prognostic models were constructed and validated in low-risk patients in World Health Organization (WHO) Functional Class I or II with cardiac index (CI) ≥2.5 liters/min/m Forty-one derivation cohort patients had CW (51.2%) during 722 ± 349 days. Changes (∆) in WHO classification and CI and absolute value of RAP were independent predictors of CW. With addition of CPET variables, peak oxygen uptake (VO The combinations of baseline VO
Sections du résumé
BACKGROUND
The added value of cardiopulmonary exercise testing (CPET) in the follow-up of patients with stable pulmonary arterial hypertension (PAH) remains undefined.
METHODS
Idiopathic, heritable, and drug-induced PAH patients free from clinical worsening (CW) after 1 year of treatment were enrolled in derivation (n = 80) and validation (n = 80) cohorts at an interval of 6 years and followed for 3 years. Prognostic models were constructed and validated in low-risk patients in World Health Organization (WHO) Functional Class I or II with cardiac index (CI) ≥2.5 liters/min/m
RESULTS
Forty-one derivation cohort patients had CW (51.2%) during 722 ± 349 days. Changes (∆) in WHO classification and CI and absolute value of RAP were independent predictors of CW. With addition of CPET variables, peak oxygen uptake (VO
CONCLUSIONS
The combinations of baseline VO
Identifiants
pubmed: 30581051
pii: S1053-2498(18)31774-1
doi: 10.1016/j.healun.2018.11.015
pii:
doi:
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
306-314Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.