ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P

Biological Transport Cell Line, Tumor Cell Membrane / metabolism Cholesterol / metabolism HEK293 Cells Hepatocytes / metabolism Humans Models, Molecular Phosphatidylinositol 4,5-Diphosphate / metabolism Protein Multimerization Protein Structure, Quaternary Receptors, Steroid / chemistry Structure-Activity Relationship
OCRL ORP1 ORP5 OSBP PI(4,5)P(2) PI4P cholesterol membrane contact sites oxysterol binding protein phosphoinositides

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
07 02 2019
Historique:
received: 17 06 2018
revised: 15 10 2018
accepted: 13 11 2018
pubmed: 26 12 2018
medline: 31 5 2019
entrez: 25 12 2018
Statut: ppublish

Résumé

Cholesterol is highly enriched at the plasma membrane (PM), and lipid transfer proteins may deliver cholesterol to the PM in a nonvesicular manner. Here, through a mini-screen, we identified the oxysterol binding protein (OSBP)-related protein 2 (ORP2) as a novel mediator of selective cholesterol delivery to the PM. Interestingly, ORP2-mediated enrichment of PM cholesterol was coupled with the removal of phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P

Identifiants

DOI: 10.1016/j.molcel.2018.11.014 PMID: 30581148
pubmed: 30581148
pii: S1097-2765(18)30984-5
doi: 10.1016/j.molcel.2018.11.014
pii:
doi:

Substances chimiques

OSBPL2 protein, human 0
Phosphatidylinositol 4,5-Diphosphate 0
Receptors, Steroid 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

458-473.e7

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Huan Wang (H)

Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Qianli Ma (Q)

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia.

Yanfei Qi (Y)

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia.

Jiangqing Dong (J)

Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Ximing Du (X)

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia.

James Rae (J)

Center for Microscopy and Microanalysis, Institute of Molecular Bioscience, the University of Queensland, St. Lucia, 4072 QLD, Australia.

Jue Wang (J)

Institute of Molecular Enzymology, Soochow University, Suzhou, Jiangsu 215123, China.

Wei-Feng Wu (WF)

Institute of Molecular Enzymology, Soochow University, Suzhou, Jiangsu 215123, China.

Andrew J Brown (AJ)

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia.

Robert G Parton (RG)

Center for Microscopy and Microanalysis, Institute of Molecular Bioscience, the University of Queensland, St. Lucia, 4072 QLD, Australia.

Jia-Wei Wu (JW)

Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; Institute of Molecular Enzymology, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: jiaweiwu@mail.tsinghua.edu.cn.

Hongyuan Yang (H)

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: h.rob.yang@unsw.edu.au.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Transport biologique › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › Phosphatidylinositol diphosphate-4,5 › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure quaternaire des protéines › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › ORP2 Delivers Cholesterol to the Plasma...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › ORP2 Delivers Cholesterol to the Plasma...