Development of high-resolution 3D MR fingerprinting for detection and characterization of epileptic lesions.
MR fingerprinting
epilepsy
focal cortical dysplasia
nodular heterotopia
quantitative MRI
tuberous sclerosis complex
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
30
05
2018
revised:
10
08
2018
accepted:
10
08
2018
pubmed:
26
12
2018
medline:
14
8
2020
entrez:
25
12
2018
Statut:
ppublish
Résumé
Conventional MRI can be limited in detecting subtle epileptic lesions or identifying active/epileptic lesions among widespread, multifocal lesions. We developed a high-resolution 3D MR fingerprinting (MRF) protocol to simultaneously provide quantitative T Prospective. National Institute of Standards and Technology (NIST) / International Society for Magnetic Resonance in Medicine (ISMRM) phantom, five healthy volunteers and 15 patients with medically intractable epilepsy undergoing presurgical evaluation with noninvasive or invasive electroclinical data. 3D MRF scans and routine clinical epilepsy MR protocols were acquired at 3 T. The accuracy of the T Phantom results were compared using R-squared, and patient results were compared using linear regression models. The phantom study showed high accuracy with the standard values, with an R The 3D MRF protocol showed potential to identify otherwise inconspicuous epileptogenic lesions from the patients with negative conventional MRI diagnosis, as well as to correlate with different levels of epileptogenicity when widespread lesions were present. 3. Technical Efficacy Stage: 3. J. Magn. Reson. Imaging 2019;49:1333-1346.
Sections du résumé
BACKGROUND
Conventional MRI can be limited in detecting subtle epileptic lesions or identifying active/epileptic lesions among widespread, multifocal lesions.
PURPOSE
We developed a high-resolution 3D MR fingerprinting (MRF) protocol to simultaneously provide quantitative T
STUDY TYPE
Prospective.
POPULATION
National Institute of Standards and Technology (NIST) / International Society for Magnetic Resonance in Medicine (ISMRM) phantom, five healthy volunteers and 15 patients with medically intractable epilepsy undergoing presurgical evaluation with noninvasive or invasive electroclinical data.
FIELD STRENGTH/SEQUENCE
3D MRF scans and routine clinical epilepsy MR protocols were acquired at 3 T.
ASSESSMENT
The accuracy of the T
STATISTICAL TESTS
Phantom results were compared using R-squared, and patient results were compared using linear regression models.
RESULTS
The phantom study showed high accuracy with the standard values, with an R
DATA CONCLUSION
The 3D MRF protocol showed potential to identify otherwise inconspicuous epileptogenic lesions from the patients with negative conventional MRI diagnosis, as well as to correlate with different levels of epileptogenicity when widespread lesions were present.
LEVEL OF EVIDENCE
3. Technical Efficacy Stage: 3. J. Magn. Reson. Imaging 2019;49:1333-1346.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1333-1346Subventions
Organisme : NINDS NIH HHS
ID : R01 NS109439
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB026764
Pays : United States
Informations de copyright
© 2018 International Society for Magnetic Resonance in Medicine.