Noteworthy effect of slight variation in aliphatic chain length of trisubstituted imidazole inhibitors against epidermal growth factor receptor L858R/T790M/C797S mutant in cancer therapy.

Binding Sites Catalytic Domain ErbB Receptors / antagonists & inhibitors Humans Hydrogen Bonding Imidazoles / chemistry Molecular Dynamics Simulation Mutagenesis, Site-Directed Neoplasms / drug therapy Protein Kinase Inhibitors / chemistry Thermodynamics
L858R/T790M/C797S MD simulation binding free energy epidermal growth factor receptor non-small-cell lung cancer

Journal

Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549

Informations de publication

Date de publication:
05 2019
Historique:
received: 07 09 2018
revised: 24 11 2018
accepted: 16 12 2018
pubmed: 26 12 2018
medline: 14 2 2020
entrez: 25 12 2018
Statut: ppublish

Résumé

11h is a very potent inhibitor against epidermal growth factor receptor triple mutation L858R/T790M/C797S (EGFR

Identifiants

DOI: 10.1111/cbdd.13467 PMID: 30582282
pubmed: 30582282
doi: 10.1111/cbdd.13467
doi:

Substances chimiques

Imidazoles 0
Protein Kinase Inhibitors 0
imidazole 7GBN705NH1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

798-810

Informations de copyright

© 2018 John Wiley & Sons A/S.

Auteurs

Farideh Badichi Akher (FB)

Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Abdolkarim Farrokhzadeh (A)

Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Mahmoud E S Soliman (MES)

Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
ORCID: 0000-0002-8711-7783

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Noteworthy effect of slight variation in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Noteworthy effect of slight variation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Noteworthy effect of slight variation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Noteworthy effect of slight variation in...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Noteworthy effect of slight variation in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Noteworthy effect of slight variation in...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Noteworthy effect of slight variation in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Mutagenèse dirigée › Noteworthy effect of slight variation in...
questionsmedicales.fr › Tumeurs › Noteworthy effect of slight variation in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Noteworthy effect of slight variation in...
questionsmedicales.fr › Phénomènes physiques › Thermodynamique › Noteworthy effect of slight variation in...