The emerging interrelation between ROCO and related kinases, intracellular Ca
Autophagy
Ca(2+)
DAPK
LRRK1
LRRK2
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
30
10
2018
revised:
13
12
2018
accepted:
17
12
2018
pubmed:
26
12
2018
medline:
26
11
2019
entrez:
25
12
2018
Statut:
ppublish
Résumé
ROCO kinases form a family of proteins characterized by kinase activity in addition to the presence of the so-called ROC (Ras of complex proteins)/COR (C-terminal of ROC) domains having a role in their GTPase activity. These are the death-associated protein kinase (DAPK) 1 and the leucine-rich repeat kinases (LRRK) 1 and 2. These kinases all play roles in cellular life and death decisions and in autophagy in particular. Related to the ROCO kinases is DAPK 2 that however cannot be classified as a ROCO protein due to the absence of the ROC/COR domains. This review aims to bring together what is known about the relation between these proteins and intracellular Ca
Identifiants
pubmed: 30582936
pii: S0167-4889(18)30530-5
doi: 10.1016/j.bbamcr.2018.12.008
pii:
doi:
Substances chimiques
Neoplasm Proteins
0
Calcium-Calmodulin-Dependent Protein Kinases
EC 2.7.11.17
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1054-1067Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.