The roles of circular RNAs in human development and diseases.
Biomarkers
Circular RNAs
Development
Diseases
Organogenesis
Systems
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
20
08
2018
revised:
10
12
2018
accepted:
14
12
2018
pubmed:
26
12
2018
medline:
14
6
2019
entrez:
25
12
2018
Statut:
ppublish
Résumé
For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.
Identifiants
pubmed: 30583227
pii: S0753-3322(18)35696-8
doi: 10.1016/j.biopha.2018.12.052
pii:
doi:
Substances chimiques
Biomarkers
0
RNA, Circular
0
RNA
63231-63-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
198-208Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.