Bacillus Calmette-Guerin infection following intravesical instillation: Does the strain matter?
Administration, Intravesical
Aged
Aged, 80 and over
Antineoplastic Agents
/ administration & dosage
BCG Vaccine
/ administration & dosage
Bacillaceae Infections
/ etiology
Carcinoma, Transitional Cell
/ drug therapy
Female
Humans
Male
Middle Aged
Retrospective Studies
Urinary Bladder Neoplasms
/ drug therapy
Urothelium
/ microbiology
BCG
Cancer de vessie
Urothelial carcinoma
Journal
Medecine et maladies infectieuses
ISSN: 1769-6690
Titre abrégé: Med Mal Infect
Pays: France
ID NLM: 0311416
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
27
11
2017
revised:
02
04
2018
accepted:
28
11
2018
pubmed:
26
12
2018
medline:
21
1
2020
entrez:
26
12
2018
Statut:
ppublish
Résumé
Intravesical BCG is the standard treatment of non-muscle invasive bladder cancer. No difference has yet been reported in the safety profiles of the various BCG strains. A nationwide multidisciplinary retrospective survey was conducted between January 2013 and December 2016 to identify cases of BCG infection and differentiate them based on the type of BCG strain used. Forty patients were identified (BCG RIVM 28; other strains 8; unknown 4). Patients treated with BCG RIVM were less severely ill, with fewer occurrences of septic shock (3.6% vs. 50%, P=0.003) and ICU admission (7.1% vs. 62.5%, P=0.003). A higher frequency of pulmonary miliaries (71.4% vs. 12.5%, P=0.005) but lower transaminase levels (mean AST 65 vs. 264 U/L, P=0.001) were observed in these patients. No difference in terms of recovery was reported. The type of BCG strain could correlate with the frequency and severity of subsequent BCG infections.
Identifiants
pubmed: 30583869
pii: S0399-077X(17)31025-9
doi: 10.1016/j.medmal.2018.11.014
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
BCG Vaccine
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
350-355Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.