The missing links within troponin.

Allosteric Regulation Amino Acid Sequence Animals Humans Protein Binding Structure-Activity Relationship Troponin C / chemistry Troponin I / chemistry
Allostery Dynamics Structural biology Thin filament Troponin

Journal

Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430

Informations de publication

Date de publication:
15 03 2019
Historique:
received: 30 08 2018
revised: 18 10 2018
accepted: 21 12 2018
pubmed: 26 12 2018
medline: 18 12 2019
entrez: 26 12 2018
Statut: ppublish

Résumé

The cardiac contraction-relaxation cycle is controlled by a sophisticated set of machinery. Of particular interest, is the revelation that allosteric networks transmit effects of binding at one site to influence troponin complex dynamics and structural-mediated signaling in often distal, functional sites in the myofilament. Our recent observations provide compelling evidence that allostery can explain the function of large-scale macromolecular events. Here we elaborate on our recent findings of interdomain communication within troponin C, using cutting-edge structural biology approaches, and highlight the importance of unveiling the unknown, distant communication networks within this system to obtain more comprehensive knowledge of how allostery impacts cardiac physiology and disease.

Identifiants

DOI: 10.1016/j.abb.2018.12.026 PMID: 30584890 PMC: PMC6377831
pubmed: 30584890
pii: S0003-9861(18)30676-3
doi: 10.1016/j.abb.2018.12.026
pmc: PMC6377831
mid: NIHMS1518355
pii:
doi:

Substances chimiques

Troponin C 0
Troponin I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

95-100

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM111886
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128683
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Mayra A Marques (MA)

Programa de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Michelle S Parvatiyar (MS)

Department of Nutrition, Food and Exercise Sciences, Florida State University, 107 Chieftan Way, Tallahassee, FL, 32306-1493, USA.

Wei Yang (W)

Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Kasha Laboratory Building, 91 Chieftan Way, Tallahassee, FL, 32306-4380, USA.

Guilherme A P de Oliveira (GAP)

Programa de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908-0733, USA. Electronic address: gaugusto@bioqmed.ufrj.br.

Jose R Pinto (JR)

Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL, 32306-4300, USA. Electronic address: jose.pinto@med.fsu.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › The missing links within troponin.
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › The missing links within troponin.
questionsmedicales.fr › Eucaryotes › Animaux › The missing links within troponin.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The missing links within troponin.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › The missing links within troponin.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › The missing links within troponin.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Troponine › Troponine C › The missing links within troponin.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Troponine › Troponine I › The missing links within troponin.