Making risky decisions to take drug: Effects of cocaine abstinence in cocaine users.
Abstinence
Cocaine
Decision making
Expected value
State dependent valuation
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
03
07
2018
revised:
20
12
2018
accepted:
21
12
2018
pubmed:
26
12
2018
medline:
1
1
2020
entrez:
26
12
2018
Statut:
ppublish
Résumé
Risky decision-making is characteristic of drug users, but little is known about the effects of circumstances, such as abstinence, on risky choice behavior in human drug users. We hypothesized that cocaine users would make more risky choices for cocaine (defined as taking a chance to receive a large number of cocaine doses as opposed to choosing to receive a fixed amount of cocaine) after 3 or 7 days of cocaine abstinence, compared to 1 day of cocaine abstinence. Six male nontreatment-seeking current cocaine smokers were enrolled in a 21-day inpatient within-subject study. Participants repeatedly smoked six 25 mg doses of cocaine during a training session and were instructed that they would be making decisions about smoking this dose throughout the study. After 1, 3 and 7 days of cocaine abstinence, participants completed a computerized task in which they repeatedly decided between receiving a guaranteed number of cocaine doses (between 1 and 5; fixed option) or receiving a chance (0.13 to 0.75) to smoke a larger number of cocaine doses (probabilistic option). After completing the computerized task, one of the participants' choices was randomly implemented and they smoked either the fixed number of cocaine doses or had the specified chance to smoke the greater number of doses. Contrary to our hypothesis, 5 of the 6 participants made fewer risky choices after 3 and 7 days of cocaine abstinence compared to one day of abstinence suggesting greater risk-aversion. Thus, even during cocaine abstinence cocaine users make rational decisions related to their drug use.
Identifiants
pubmed: 30584902
pii: S0091-3057(18)30343-5
doi: 10.1016/j.pbb.2018.12.008
pmc: PMC7059600
mid: NIHMS1566517
pii:
doi:
Substances chimiques
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-26Subventions
Organisme : NIDA NIH HHS
ID : K05 DA031749
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA021319
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024156
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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