A single run, rapid polarity switching method for determination of 30 pharmaceuticals and personal care products in waste water using Q-Exactive Orbitrap high resolution accurate mass spectrometry.
Benzhydryl Compounds
/ analysis
Chemistry Techniques, Analytical
/ methods
Chromatography, High Pressure Liquid
Limit of Detection
Mass Spectrometry
Pharmaceutical Preparations
/ analysis
Phenols
/ analysis
Reproducibility of Results
Solid Phase Extraction
Wastewater
/ chemistry
Water Pollutants, Chemical
/ analysis
Effluent
Egypt
Non-target screening
Pharmaceuticals and personal care products
Q Exactive Orbitrap
Surface water
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
15 Mar 2019
15 Mar 2019
Historique:
received:
24
03
2018
revised:
09
08
2018
accepted:
16
12
2018
pubmed:
28
12
2018
medline:
18
4
2019
entrez:
28
12
2018
Statut:
ppublish
Résumé
The analytical capability of the UPLC-Q Exactive™ Orbitrap MS was exploited for simultaneous determination of 30 acidic and basic PPCPs in a single run, using rapid polarity switching of the electrospray ionisation source. Full scan MS mode at resolution of 35,000 FWHM, Automatic gain control (AGC) target of 1E6 ions at injection time of 50 ms provided the optimum parameters for high sensitivity, together with sufficient data points per peak (≥15) for improved reproducibility. In addition to chromatographic retention times, method selectivity was achieved via applying high resolution accurate mass with low mass tolerance filter (<5 ppm) for identification of each target compound. Six-point linear calibration curves (R
Identifiants
pubmed: 30587347
pii: S0021-9673(18)31552-8
doi: 10.1016/j.chroma.2018.12.033
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Pharmaceutical Preparations
0
Phenols
0
Waste Water
0
Water Pollutants, Chemical
0
bisphenol A
MLT3645I99
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
68-76Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.