Genetic Analysis of the Organization, Development, and Plasticity of Corneal Innervation in Mice.
aging
confocal microscopy
cornea
corneal innervation
mouse genetics
neuropilin
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
02
06
2018
revised:
05
10
2018
accepted:
24
11
2018
pubmed:
28
12
2018
medline:
18
12
2019
entrez:
28
12
2018
Statut:
ppublish
Résumé
The cornea has the densest sensory innervation of the body, originating primarily from neurons in the trigeminal ganglion. The basic principles of cornea nerve patterning have been established many years ago using classic neuroanatomical methods, such as immunocytochemistry and electrophysiology. Our understanding of the morphology and distribution of the sensory nerves in the skin has considerably progressed over the past few years through the generation and analysis of a variety of genetically modified mouse lines. Surprisingly, these lines were not used to study corneal axons. Here, we have screened a collection of transgenic and knockin mice (of both sexes) to select lines allowing the visualization and genetic manipulation of corneal nerves. We identified multiple lines, including some in which different types of corneal axons can be simultaneously observed with fluorescent proteins expressed in a combinatorial manner. We also provide the first description of the morphology and arborization of single corneal axons and identify three main types of branching pattern. We applied this genetic strategy to the analysis of corneal nerve development and plasticity. We provide direct evidence for a progressive reduction of the density of corneal innervation during aging. We also show that the semaphorin receptor neuropilin-1 acts cell-autonomously to control the development of corneal axons and that early axon guidance defects have long-term consequences on corneal innervation.
Identifiants
pubmed: 30587537
pii: JNEUROSCI.1401-18.2018
doi: 10.1523/JNEUROSCI.1401-18.2018
pmc: PMC6381234
doi:
Substances chimiques
Tamoxifen
094ZI81Y45
Neuropilin-1
144713-63-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1150-1168Informations de copyright
Copyright © 2019 the authors 0270-6474/19/391150-19$15.00/0.
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