IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses.
CD8 T cells
interferons
interleukin 15
myeloid cells
tumors
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 01 2019
08 01 2019
Historique:
pubmed:
28
12
2018
medline:
13
3
2019
entrez:
28
12
2018
Statut:
ppublish
Résumé
Previous studies have provided evidence that IL-15 expression within human tumors is crucial for optimal antitumor responses; however, the regulation of IL-15 within the tumor microenvironment (TME) is unclear. We report herein, in analyses of mice implanted with various tumor cell lines, soluble IL-15/IL-15Rα complexes (sIL-15 complexes) are abundant in the interstitial fluid of tumors with expression preceding the infiltration of tumor-infiltrating lymphocytes. Moreover, IL-15 as well as type I IFN, which regulates IL-15, was required for establishing normal numbers of CD8 T cells and natural killer cells in tumors. Depending on tumor type, both the tumor and the stroma are sources of sIL-15 complexes. In analyses of IL-15 reporter mice, most myeloid cells in the TME express IL-15 with CD11b
Identifiants
pubmed: 30587590
pii: 1814642116
doi: 10.1073/pnas.1814642116
pmc: PMC6329954
doi:
Substances chimiques
Il15ra protein, mouse
0
Interleukin-15
0
Membrane Proteins
0
Neoplasm Proteins
0
Receptors, Interleukin-15
0
Sting1 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
599-608Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009598
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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