Heteroplasmic Mutations and Polymorphisms in the
Cyb gene
dog
mast cell tumours
mitochondrial DNA
mtDNA
mutations
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
05
09
2018
revised:
08
10
2018
accepted:
12
10
2018
entrez:
28
12
2018
pubmed:
28
12
2018
medline:
6
4
2019
Statut:
ppublish
Résumé
Identification of mutations and polymorphisms in the cytochrome b gene (Cyb) of mitochondrial DNA (mtDNA) in canine mast cell tumours and determinatiion of their association with the process of neoplastic transformation. The samples comprised tumour tissues and blood obtained from 34 dogs of various breeds. Mutations and polymorphisms in the Cyb gene were detected using amplification and sequencing methods. Heteroplasmic mutations were detected at seven positions of mtDNA in 86% of the individuals. Blood and tumour heteroplasmy were recorded at five nucleotide positions of the Cyb gene, whereas tumour heteroplasmy was detected at two positions. Polymorphisms were detected at 14 Cyb gene positions in in the blood of 91% of dogs with mast cell tumours. The presence of numerous mutations and polymorphisms of Cyb in the blood and tumour tissues and the high frequency of heteroplasmy indicate their involvement in the process of neoplastic transformation in dogs.
Identifiants
pubmed: 30587603
pii: 33/1/57
doi: 10.21873/invivo.11439
pmc: PMC6364090
doi:
Substances chimiques
Cytochromes b
9035-37-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-63Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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