Human papilloma virus-associated squamous cell carcinoma of the larynx in an 18-year-old woman.
Adolescent
Biopsy, Needle
Carcinoma, Squamous Cell
/ pathology
Female
Follow-Up Studies
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
/ administration & dosage
Humans
Immunohistochemistry
Laryngeal Neoplasms
/ pathology
Laryngectomy
/ methods
Laryngoscopy
/ methods
Neoplasm Invasiveness
Neoplasm Staging
Papillomaviridae
/ isolation & purification
Papillomavirus Infections
/ complications
Treatment Outcome
Vaccination
/ methods
human papilloma virus
larynx
squamous cell carcinoma
transmission
vaccination
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
12
10
2017
revised:
10
06
2018
accepted:
21
11
2018
pubmed:
28
12
2018
medline:
10
10
2020
entrez:
28
12
2018
Statut:
ppublish
Résumé
Human papilloma virus (HPV)-associated malignancies are considered to be sexually transmitted diseases. We report a HPV-positive larynx cancer in an 18-year-old female clarinet player, despite vaccination with the quadrivalent HPV-6-11-16-18-vaccine Gardasil (Merck Sharp & Dohme Corp., West Point, Pennsylvania). The patient showed no evidence of genito-oral infection but showed some evidence for oral-oral HPV transmission through the sharing of saliva-infested clarinet mouthpieces. A right vocal cord lesion of benign appearance was removed via free margin resection. Histopathology revealed a microinvasive squamous cell carcinoma inside a zone of high-grade dysplasia that was positive for HPV-45. No tumor recurrence was observed during a 4-year follow-up evaluation. Benign lesion appearance and quadrivalent HPV vaccine status do not exclude HPV-associated malignancies. In our patient, the Gardasil vaccine did not provide crossover protection against HPV 45 infection. HPV-associated disease may not necessarily be transmitted via sexual practice patterns alone.
Sections du résumé
BACKGROUND
Human papilloma virus (HPV)-associated malignancies are considered to be sexually transmitted diseases.
METHODS
We report a HPV-positive larynx cancer in an 18-year-old female clarinet player, despite vaccination with the quadrivalent HPV-6-11-16-18-vaccine Gardasil (Merck Sharp & Dohme Corp., West Point, Pennsylvania). The patient showed no evidence of genito-oral infection but showed some evidence for oral-oral HPV transmission through the sharing of saliva-infested clarinet mouthpieces. A right vocal cord lesion of benign appearance was removed via free margin resection.
RESULTS
Histopathology revealed a microinvasive squamous cell carcinoma inside a zone of high-grade dysplasia that was positive for HPV-45. No tumor recurrence was observed during a 4-year follow-up evaluation.
CONCLUSION
Benign lesion appearance and quadrivalent HPV vaccine status do not exclude HPV-associated malignancies. In our patient, the Gardasil vaccine did not provide crossover protection against HPV 45 infection. HPV-associated disease may not necessarily be transmitted via sexual practice patterns alone.
Substances chimiques
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
E59-E61Informations de copyright
© 2018 Wiley Periodicals, Inc.