The In Vitro Evaluation of Povidone-Iodine Against Multiple Ocular Adenoviral Types.
None
adenovirus
antiviral
epidemic keratoconjunctivitis
povidone-iodine
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
ISSN: 1557-7732
Titre abrégé: J Ocul Pharmacol Ther
Pays: United States
ID NLM: 9511091
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
28
12
2018
medline:
1
7
2020
entrez:
28
12
2018
Statut:
ppublish
Résumé
Povidone-iodine (P-I) is being touted as a topical antiviral treatment for eye infections caused by adenovirus (Ad). This study evaluated the in vitro antiviral activity of the several P-I concentrations previously used in clinical studies against multiple ocular Ad types commonly associated with eye infections. The antiviral activity of four concentrations of P-I was compared to vehicle for seven types of Ad after incubating the P-I with Ad at 33°C for various lengths of time. Following incubation and neutralization of the P-I with sodium thiosulfate, viral titers were determined for each Ad type and time point. Virucidal (99.9%, ≥3-Log P-I produced greater than 3-Log
Identifiants
pubmed: 30589605
doi: 10.1089/jop.2018.0122
pmc: PMC6450451
doi:
Substances chimiques
Antiviral Agents
0
Povidone-Iodine
85H0HZU99M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
132-136Références
J Hosp Infect. 2004 May;57(1):59-66
pubmed: 15142717
Ann N Y Acad Sci. 1950 Aug;53(1):172-82
pubmed: 15433173
Antimicrob Agents Chemother. 2006 Apr;50(4):1419-24
pubmed: 16569860
Invest Ophthalmol Vis Sci. 2006 May;47(5):2021-6
pubmed: 16639011
Klin Monbl Augenheilkd. 2006 May;223(5):349-52
pubmed: 16705502
Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4171-6
pubmed: 17724203
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5295-9
pubmed: 19516011
Adv Ther. 2009 Aug;26(8):776-83
pubmed: 19756415
J Ocul Pharmacol Ther. 2012 Feb;28(1):53-8
pubmed: 21916618
Invest Ophthalmol Vis Sci. 1994 Nov;35(12):4135-43
pubmed: 7960596
Cornea. 1994 Sep;13(5):435-9
pubmed: 7995068
Dermatology. 1997;195 Suppl 2:10-3
pubmed: 9403249
Invest Ophthalmol Vis Sci. 1998 Mar;39(3):532-6
pubmed: 9501863