Oxidative stress: Normal pregnancy versus preeclampsia.

Animals Antioxidants / therapeutic use Endothelial Cells / metabolism Female Free Radicals Humans Ischemia / metabolism Melatonin / metabolism Oxidation-Reduction Oxidative Stress / physiology Placenta / metabolism Pre-Eclampsia / drug therapy Pregnancy / metabolism Reactive Nitrogen Species / metabolism Reactive Oxygen Species / metabolism Signal Transduction
Oxidative stress Preeclampsia RNS ROS

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 02 2020
Historique:
received: 15 10 2018
revised: 22 11 2018
accepted: 05 12 2018
pubmed: 28 12 2018
medline: 10 7 2020
entrez: 28 12 2018
Statut: ppublish

Résumé

The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which results in high amounts of circulating reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS play an important role as secondary messengers in many intracellular signalling cascades. However, they can also exert critical effects on pathological processes involving the pregnant woman. ROS, RNS and antioxidants establish a balance that determines the oxidation status of animals and humans. This review focuses on the mechanism of oxidative stress in pregnancy as well as its involvement and consequences on the human pregnancy-specific clinical syndrome preeclampsia.

Identifiants

DOI: 10.1016/j.bbadis.2018.12.005 PMID: 30590104
pubmed: 30590104
pii: S0925-4439(18)30491-5
doi: 10.1016/j.bbadis.2018.12.005
pii:
doi:

Substances chimiques

Antioxidants 0
Free Radicals 0
Reactive Nitrogen Species 0
Reactive Oxygen Species 0
Melatonin JL5DK93RCL

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

165354

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Delia I Chiarello (DI)

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.

Cilia Abad (C)

Center for Biophysics and Biochemistry (CBB), Venezuelan Institute for Scientific Research (IVIC), AP 21827, Caracas 1020A, Venezuela; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic.

Deliana Rojas (D)

Center for Biophysics and Biochemistry (CBB), Venezuelan Institute for Scientific Research (IVIC), AP 21827, Caracas 1020A, Venezuela.

Fernando Toledo (F)

Department of Basic Sciences, Faculty of Sciences, Universidad del Bío-Bío, Chillán 3780000, Chile; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.

Carmen M Vázquez (CM)

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.

Alfonso Mate (A)

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.

Luis Sobrevia (L)

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, 4029, Queensland, Australia; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile. Electronic address: lsobrevia@uc.cl.

Reinaldo Marín (R)

Center for Biophysics and Biochemistry (CBB), Venezuelan Institute for Scientific Research (IVIC), AP 21827, Caracas 1020A, Venezuela. Electronic address: reinaldomarin@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Mélatonine › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Structures de l'embryon › Placenta › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Composés chimiques organiques › Composés nitrosés › Espèces réactives de l'azote › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Oxidative stress: Normal pregnancy versus preeclampsia.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Oxidative stress: Normal pregnancy versus preeclampsia.