Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.
Aminobutyrates
/ administration & dosage
Animals
Disease Models, Animal
Fluorouracil
/ administration & dosage
Humans
Mice
Neoplasms
/ complications
Organophosphonates
/ administration & dosage
Reactive Oxygen Species
/ metabolism
Stomatitis
/ chemically induced
gamma-Glutamyltransferase
/ antagonists & inhibitors
GGT inhibitor
Oral mucositis
chemotherapy
mouse model
wound healing
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
15
11
2018
revised:
02
12
2018
accepted:
04
12
2018
entrez:
29
12
2018
pubmed:
29
12
2018
medline:
8
1
2019
Statut:
ppublish
Résumé
Oral mucositis (OM) induced by cancer chemotherapy has a high incidence and serious symptoms, which often force chemotherapy to be stopped. GGsTop is a newly-discovered gamma-glutamyl transpeptidase (GGT) inhibitor. Previous research suggested that inhibition of GGT suppressed reactive oxygen species and induced the production of collagen and elastin. We hypothesized that GGsTop could safely treat OM. A mouse model of OM was treated with GGsTop and ulcer area, weight, and white blood cell count were determined. The treatment effect was also evaluated by hematoxylin-eosin and collagen staining. The therapeutic effect of GGsTop was better than that of an existing drug and may be safely used in combination with chemotherapy. Furthermore, GGsTop promoted collagen production in oral mucosa. GGsTop treated OM quickly and safely. GGsTop is highly valuable for use as a treatment for OM.
Sections du résumé
BACKGROUND
BACKGROUND
Oral mucositis (OM) induced by cancer chemotherapy has a high incidence and serious symptoms, which often force chemotherapy to be stopped. GGsTop is a newly-discovered gamma-glutamyl transpeptidase (GGT) inhibitor. Previous research suggested that inhibition of GGT suppressed reactive oxygen species and induced the production of collagen and elastin. We hypothesized that GGsTop could safely treat OM.
MATERIALS AND METHODS
METHODS
A mouse model of OM was treated with GGsTop and ulcer area, weight, and white blood cell count were determined. The treatment effect was also evaluated by hematoxylin-eosin and collagen staining.
RESULTS
RESULTS
The therapeutic effect of GGsTop was better than that of an existing drug and may be safely used in combination with chemotherapy. Furthermore, GGsTop promoted collagen production in oral mucosa.
CONCLUSION
CONCLUSIONS
GGsTop treated OM quickly and safely. GGsTop is highly valuable for use as a treatment for OM.
Identifiants
pubmed: 30591459
pii: 39/1/201
doi: 10.21873/anticanres.13098
doi:
Substances chimiques
2-amino-4-((3-(carboxymethyl)phenyl)(methyl)phosphono)butanoic acid
0
Aminobutyrates
0
Organophosphonates
0
Reactive Oxygen Species
0
gamma-Glutamyltransferase
EC 2.3.2.2
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
201-206Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.