CNS Delivery and Anti-Inflammatory Effects of Intranasally Administered Cyclosporine-A in Cationic Nanoformulations.
Administration, Intranasal
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Cell Line
Central Nervous System
Cyclosporine
/ administration & dosage
Cytokines
/ metabolism
Drug Compounding
Drug Delivery Systems
Emulsions
Fatty Acids, Omega-3
Inflammation
/ chemically induced
Linseed Oil
Lipopolysaccharides
Magnetic Resonance Imaging
Male
Nanostructures
Rats
Rats, Sprague-Dawley
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
26
10
2018
accepted:
10
12
2018
pubmed:
29
12
2018
medline:
24
12
2019
entrez:
29
12
2018
Statut:
ppublish
Résumé
The main objective of this study was to develop and evaluate the CNS delivery efficiency, distribution, therapeutic efficacy, and safety of cyclosporine A (CSA) using a cationic oil-in-water nanoemulsion system upon intranasal administration. An omega-3 fatty acid-rich, flaxseed oil-based nanoemulsion was used for intranasal delivery to the brain, and further magnetic resonance imaging (MRI) was used to evaluate and confirm the transport of the positively charged CSA nanoemulsion (CSA-NE) in CNS. Furthermore, the anti-inflammatory potential of CSA peptide was evaluated using the lipopolysaccharide (LPS) model of neuroinflammation in rats. CSA-NE showed a good safety profile when tested in vitro in RPMI 2650 cells. Upon intranasal administration in rats, the nanoemulsion delivery system showed higher uptake in major regions of the brain based on changes in MRI T
Identifiants
pubmed: 30591529
pii: jpet.118.254672
doi: 10.1124/jpet.118.254672
pmc: PMC6806630
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Cytokines
0
Emulsions
0
Fatty Acids, Omega-3
0
Lipopolysaccharides
0
Linseed Oil
8001-26-1
Cyclosporine
83HN0GTJ6D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
843-854Informations de copyright
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.
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