Purinergic receptors in neurogenic processes.

Adenosine Triphosphate Animals Brain / cytology Calcium / metabolism Calcium Signaling Cell Differentiation Cell Proliferation Hippocampus / cytology Humans Nervous System Neurogenesis / physiology Purines / metabolism Receptors, Purinergic / metabolism Receptors, Purinergic P2X7 / metabolism Receptors, Purinergic P2Y1 / metabolism Signal Transduction / physiology
Adult neurogenesis Embryonic neurogenesis Purinergic signaling

Journal

Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818

Informations de publication

Date de publication:
09 2019
Historique:
received: 08 09 2018
revised: 28 11 2018
accepted: 20 12 2018
pubmed: 30 12 2018
medline: 5 8 2020
entrez: 30 12 2018
Statut: ppublish

Résumé

Neurogenesis is a process of generating functional neurons, which occurs during embryonic and adult stages in mammals. While neurogenesis during development phase is characterized by intensive proliferation activity in all regions of the brain to form the architecture and neural function of the nervous system, adult neurogenesis occurs with less intensity in two brain regions and is involved in the maintenance of neurogenic niches, local repair, memory and cognitive functions in the hippocampus. Taking such differences into account, the understanding of molecular mechanisms involved in cell differentiation in developmental stages and maintenance of the nervous system is an important research target. Although embryonic and adult neurogenesis presents several differences, signaling through purinergic receptors participates in this process throughout life. For instance, while embryonic neurogenesis involves P2X7 receptor down-regulation and calcium waves triggered by P2Y1 receptor stimulation, adult neurogenesis may be enhanced by increased activity of A

Identifiants

DOI: 10.1016/j.brainresbull.2018.12.013 PMID: 30593881
pubmed: 30593881
pii: S0361-9230(18)30690-7
doi: 10.1016/j.brainresbull.2018.12.013
pii:
doi:

Substances chimiques

Purines 0
Receptors, Purinergic 0
Receptors, Purinergic P2X7 0
Receptors, Purinergic P2Y1 0
Adenosine Triphosphate 8L70Q75FXE
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3-11

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

D E Ribeiro (DE)

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil.

T Glaser (T)

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil.

Á Oliveira-Giacomelli (Á)

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil.

H Ulrich (H)

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil. Electronic address: henning@iq.usp.br.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Eucaryotes › Animaux › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Système nerveux › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2X › Récepteurs purinergiques P2X7 › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2Y › Récepteurs purinergiques P2Y1 › Purinergic receptors in neurogenic processes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Purinergic receptors in neurogenic processes.