Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study.
Adult
Diethylstilbestrol
/ toxicity
Endocrine Disruptors
/ toxicity
Female
Humans
Maternal-Fetal Exchange
Menstruation Disturbances
/ epidemiology
Mothers
National Cancer Institute (U.S.)
Pregnancy
Premature Birth
/ epidemiology
Prenatal Exposure Delayed Effects
/ epidemiology
Reproduction
Risk
United States
Young Adult
DES
Diethylstilbestrol
Epigenetic
Granddaughters
Intergenerational
Third generation women
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
07
08
2018
revised:
18
11
2018
accepted:
26
12
2018
pubmed:
31
12
2018
medline:
11
4
2019
entrez:
31
12
2018
Statut:
ppublish
Résumé
Animal studies suggest that prenatal exposure to diethylstilbestrol (DES) causes epigenetic alterations in primordial germ cells that affect the next generation, but human studies are sparse. We assessed hormonally mediated outcomes in third generation women whose mothers were prenatally DES-exposed and unexposed. Compared to the unexposed, DES-exposed third generation women had an increased risk of irregular menses and amenorrhea; the respective prevalence ratios and 95% confidence intervals (CI) in follow-up data were 1.32 (95% CI: 1.10, 1.60) and 1.26 (95% CI: 1.06, 1.49); associations were more apparent in third generation women whose prenatally DES-exposed mothers were affected by vaginal epithelial changes. The follow-up data also indicated an association with preterm delivery (relative risk (RR): 1.54; 95% CI: 1.35, 1.75). DES third generation women may have an increased risk of irregular menstrual cycles, amenorrhea, and preterm delivery, consistent with inter-generational effects of endocrine disrupting chemical exposure in humans.
Sections du résumé
BACKGROUND
Animal studies suggest that prenatal exposure to diethylstilbestrol (DES) causes epigenetic alterations in primordial germ cells that affect the next generation, but human studies are sparse.
METHODS
We assessed hormonally mediated outcomes in third generation women whose mothers were prenatally DES-exposed and unexposed.
RESULTS
Compared to the unexposed, DES-exposed third generation women had an increased risk of irregular menses and amenorrhea; the respective prevalence ratios and 95% confidence intervals (CI) in follow-up data were 1.32 (95% CI: 1.10, 1.60) and 1.26 (95% CI: 1.06, 1.49); associations were more apparent in third generation women whose prenatally DES-exposed mothers were affected by vaginal epithelial changes. The follow-up data also indicated an association with preterm delivery (relative risk (RR): 1.54; 95% CI: 1.35, 1.75).
CONCLUSION
DES third generation women may have an increased risk of irregular menstrual cycles, amenorrhea, and preterm delivery, consistent with inter-generational effects of endocrine disrupting chemical exposure in humans.
Identifiants
pubmed: 30594671
pii: S0890-6238(18)30468-4
doi: 10.1016/j.reprotox.2018.12.008
pmc: PMC6382553
mid: NIHMS1518362
pii:
doi:
Substances chimiques
Endocrine Disruptors
0
Diethylstilbestrol
731DCA35BT
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-38Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL133600
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CP001012
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CP051019
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CP055511
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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