Clinical Manifestations and Long-term Outcomes of IgG4-Related Kidney and Retroperitoneal Involvement in a United Kingdom IgG4-Related Disease Cohort.
IgG4-related disease
membranous nephropathy
retroperitoneal fibrosis
tubulointerstitial nephritis
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
29
06
2018
revised:
15
08
2018
accepted:
27
08
2018
entrez:
1
1
2019
pubmed:
1
1
2019
medline:
1
1
2019
Statut:
epublish
Résumé
IgG4-related disease (IgG4-RD) is a relapsing multisystem fibro-inflammatory disease, which may involve the kidney (IgG4-related kidney disease [IgG4-RKD]) and retroperitoneum (IgG4-related retroperitoneal fibrosis [IgG4-RPF]). The aim of this study was to describe IgG4-RKD and IgG4-RPF in the United Kingdom. We conducted a retrospective observational study of patients with IgG4-RKD and IgG4-RPF in a multicenter IgG4-RD cohort. Data were collected through review of medical records. We describe clinical parameters at baseline, histological and radiological findings, treatment, and patient outcomes. Of 154 patients with IgG4-RD, 14 (9.1%) had IgG4-RKD, 10 (6.5%) had IgG4-RPF, and 4 (2.6%) had both. Patients were aged 58.2 ± 14.2 years, and 26 (92.9%) were male. Creatinine at presentation was worse in those with intrinsic renal disease (229 μmol/l vs. 110 μmol/l; IgG4-RKD and IgG4-RPF represent major organ manifestations of IgG4-RD, and should be identified early with prompt treatment to prevent progression to ESRD.
Identifiants
pubmed: 30596168
doi: 10.1016/j.ekir.2018.08.011
pii: S2468-0249(18)30196-7
pmc: PMC6308386
doi:
Types de publication
Journal Article
Langues
eng
Pagination
48-58Références
Intern Med. 2013;52(14):1545-51
pubmed: 23857085
Am J Gastroenterol. 2014 Oct;109(10):1675-1683
pubmed: 25155229
Rheumatology (Oxford). 2015 Sep;54(9):1541-8
pubmed: 26070939
Mod Pathol. 2012 Sep;25(9):1181-92
pubmed: 22596100
Ther Adv Chronic Dis. 2013 Jul;4(4):167-85
pubmed: 23819020
Medicine (Baltimore). 2012 Jan;91(1):49-56
pubmed: 22198501
Am J Surg Pathol. 2009 Dec;33(12):1833-9
pubmed: 19950407
Kidney Int. 2013 Oct;84(4):826-33
pubmed: 23698232
Oncotarget. 2018 Apr 20;9(30):21337-21347
pubmed: 29765543
Clin Exp Nephrol. 2011 Oct;15(5):615-626
pubmed: 21898030
Int J Rheumatol. 2012;2012:609795
pubmed: 22899937
Am J Transplant. 2018 Jul;18(7):1799-1803
pubmed: 29607610
Lancet. 2015 Apr 11;385(9976):1460-71
pubmed: 25481618
Nat Rev Nephrol. 2015 Oct;11(10):599-609
pubmed: 26122730
Respir Med. 2017 Nov;132:117-121
pubmed: 29229083
J Am Soc Nephrol. 2011 Jul;22(7):1343-52
pubmed: 21719792
Medicine (Baltimore). 2015 Aug;94(32):e1275
pubmed: 26266361
BMC Med. 2006 Oct 06;4:23
pubmed: 17026742
Arthritis Rheumatol. 2015 Sep;67(9):2466-75
pubmed: 25988916
Oncotarget. 2017 Dec 7;9(2):2858-2865
pubmed: 29416818
Kidney Int. 2013 Mar;83(3):455-62
pubmed: 23254897
Am J Surg Pathol. 2010 Dec;34(12):1812-9
pubmed: 21107087
Kidney Int. 2010 Nov;78(10):1016-23
pubmed: 20720530
Arthritis Res Ther. 2017 Dec 01;19(1):262
pubmed: 29191210
Scand J Rheumatol. 2016;45(2):135-45
pubmed: 26398142
Kidney Int. 2014 Feb;85(2):251-7
pubmed: 24107849
Rheumatology (Oxford). 2015 Nov;54(11):1982-90
pubmed: 26106212
Mod Rheumatol. 2012 Feb;22(1):21-30
pubmed: 22218969
Medicine (Baltimore). 2015 Apr;94(15):e680
pubmed: 25881845
EBioMedicine. 2015 Mar 06;2(5):456-66
pubmed: 26137589
BMC Musculoskelet Disord. 2016 Jan 05;17:2
pubmed: 26728714
Arthritis Rheum. 2012 Oct;64(10):3061-7
pubmed: 22736240
Arthritis Rheumatol. 2016 Sep;68(9):2290-9
pubmed: 26990055
N Engl J Med. 2012 Feb 9;366(6):539-51
pubmed: 22316447
Chin Med J (Engl). 2016 Jul 5;129(13):1525-32
pubmed: 27364787
Medicine (Baltimore). 2013 Mar;92(2):82-91
pubmed: 23429355
Int J Rheumatol. 2012;2012:139409
pubmed: 22654915
J Allergy Clin Immunol. 2014 Jan;133(1):267-70.e1-6
pubmed: 24074895
J Gastroenterol. 2007 May;42 Suppl 18:39-41
pubmed: 17520222