Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins.
GFR
atherosclerosis
creatinine
cystatin C
kidney
mortality
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
20
05
2018
revised:
30
08
2018
accepted:
04
09
2018
entrez:
1
1
2019
pubmed:
1
1
2019
medline:
1
1
2019
Statut:
epublish
Résumé
Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFR Four patient cohorts were included: 1 cohort with normal mGFR without SPS, 1 with normal mGFR with SPS, 1 with reduced mGFR without SPS, and 1 with reduced mGFR with SPS. The plasma levels of 177 selected proteins were analyzed. Differences in the levels of 30 proteins were specific for SPS; 31 differences were specific for patients with both SPS and reduced mGFR; and 27 were specific for reduced mGFR. Eighteen of the differences specific for SPS concerned proteins described as promoting, or being associated with, atherosclerosis. Twelve of the differences specific for patients with both SPS and reduced mGFR and 10 of the differences specific for reduced mGFR also concerned proteins described as promoting, or being associated with, atherosclerosis. Almost all (82 of 88) of the concentration differences represented increased levels. For SPS, but not for reduced mGFR, a correlation between protein size and increase in level was observed, with smaller proteins being associated with higher levels. The high mortality in shrunken pore syndrome might be caused by the accumulation of atherosclerosis-promoting proteins in this condition.
Identifiants
pubmed: 30596170
doi: 10.1016/j.ekir.2018.09.002
pii: S2468-0249(18)30200-6
pmc: PMC6308389
doi:
Types de publication
Journal Article
Langues
eng
Pagination
67-79Références
Atherosclerosis. 2017 Sep;264:36-43
pubmed: 28759844
Scand J Clin Lab Invest. 2001;61(7):575-80
pubmed: 11763416
Circulation. 2006 May 16;113(19):2301-12
pubmed: 16682613
Drug Des Devel Ther. 2014 Nov 27;8:2359-71
pubmed: 25473269
Nephrol Dial Transplant. 2017 Apr 01;32(4):663-670
pubmed: 28340079
Electron Physician. 2015 Sep 16;7(5):1270-6
pubmed: 26435827
Scand J Clin Lab Invest. 1979 Nov;39(7):619-26
pubmed: 119302
Br J Pharmacol. 2012 Jun;166(3):912-23
pubmed: 21895630
Am J Physiol. 1996 Feb;270(2 Pt 2):F338-43
pubmed: 8779896
Scand J Clin Lab Invest. 2016 Jul;76(4):341-3
pubmed: 26981764
Circulation. 2006 Feb 7;113(5):722-31
pubmed: 16461845
Circulation. 2004 Oct 19;110(16):2342-8
pubmed: 15477399
Mol Med. 2014 Oct 14;20:456-65
pubmed: 25032953
Nat Med. 2015 Jul;21(7):820-6
pubmed: 26099046
PLoS One. 2014 Apr 22;9(4):e95192
pubmed: 24755770
Kidney Int. 2004 Apr;65(4):1416-21
pubmed: 15086483
Biomed Res Int. 2014;2014:893106
pubmed: 24868552
JAMA. 2005 Apr 13;293(14):1737-45
pubmed: 15827312
Clin Chem Lab Med. 2014 Jun;52(6):815-24
pubmed: 24334413
Endocrinology. 2011 Dec;152(12):4915-26
pubmed: 22009730
Acta Obstet Gynecol Scand. 2007;86(8):921-6
pubmed: 17653875
Eur J Prev Cardiol. 2017 Oct;24(15):1576-1583
pubmed: 28762762
Scand J Clin Lab Invest. 2016;76(1):74-81
pubmed: 26647957
Circulation. 2004 Nov 30;110(22):3493-500
pubmed: 15557373
Atherosclerosis. 2014 Oct;236(2):360-5
pubmed: 25128974
Metabolism. 2013 Jun;62(6):778-85
pubmed: 23398844
BMC Cardiovasc Disord. 2016 Sep 05;16(1):171
pubmed: 27596252
Inflamm Res. 2011 Sep;60(9):889-95
pubmed: 21656154
J Clin Invest. 1991 Oct;88(4):1121-7
pubmed: 1843454
Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2394-400
pubmed: 11073843
Innate Immun. 2015 Apr;21(3):255-65
pubmed: 24663337
Proteomics Clin Appl. 2018 May;12(3):e1700067
pubmed: 29281176
Circulation. 2004 May 11;109(18):2175-80
pubmed: 15117849
Biochem J. 2003 Jan 15;369(Pt 2):213-25
pubmed: 12215171
Cardiol Rev. 2014 May-Jun;22(3):147-51
pubmed: 24618929
Scand J Clin Lab Invest. 2011 Apr;71(2):145-9
pubmed: 21198422
Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2733-41
pubmed: 21852561
Mediators Inflamm. 2012;2012:506283
pubmed: 22911112
Scand J Clin Lab Invest. 2016 Nov;76(7):568-574
pubmed: 27622713
World J Diabetes. 2014 Oct 15;5(5):678-88
pubmed: 25317245
Scand J Clin Lab Invest. 2015 Jul;75(4):333-40
pubmed: 25919022
Scand J Clin Lab Invest. 2002;62(2):141-7
pubmed: 12004930
Atherosclerosis. 2011 Jul;217(1):113-9
pubmed: 21536288
Clin Chem. 2014 Jul;60(7):974-86
pubmed: 24829272
J Biol Chem. 2010 Jul 23;285(30):23496-505
pubmed: 20504763
J Lab Clin Med. 1984 Dec;104(6):955-61
pubmed: 6438261
EJIFCC. 2017 Dec 19;28(4):268-276
pubmed: 29333146
Circ Cardiovasc Genet. 2014 Oct;7(5):634-41
pubmed: 25053723
Kidney Int. 2001 Nov;60(5):1885-92
pubmed: 11703607
JAMA. 2011 Apr 20;305(15):1545-52
pubmed: 21482744
Am J Kidney Dis. 2014 Sep;64(3):411-24
pubmed: 24840668
Atherosclerosis. 2009 Jan;202(1):92-102
pubmed: 18495127
J Heart Lung Transplant. 2011 Aug;30(8):955-62
pubmed: 21620738
Scand J Clin Lab Invest. 2012 Feb;72(1):73-7
pubmed: 22121923
Atherosclerosis. 2006 Nov;189(1):47-60
pubmed: 16580676
Thromb Haemost. 2009 Aug;102(2):206-14
pubmed: 19652870
Scand J Clin Lab Invest. 2010 Apr;70(2):65-70
pubmed: 20170415
Atherosclerosis. 2011 Jul;217(1):227-33
pubmed: 21481392
Transl Res. 2016 Mar;169:80-90.e1-2
pubmed: 26637934
Coron Artery Dis. 2010 Nov;21(7):435-40
pubmed: 20679894
Scand J Clin Lab Invest. 2016 Sep;76(5):379-85
pubmed: 27242017
Int J Cardiol. 2015;186:219-25
pubmed: 25828120
Ann Clin Biochem. 2015 Nov;52(Pt 6):632-7
pubmed: 25995285
N Engl J Med. 2005 May 19;352(20):2049-60
pubmed: 15901858
Biochem Biophys Res Commun. 2002 Apr 5;292(3):781-6
pubmed: 11922634
Am J Kidney Dis. 2002 Aug;40(2):221-6
pubmed: 12148093
Immun Ageing. 2016 Aug 24;13(1):25
pubmed: 27559355
Scand J Clin Lab Invest. 2007;67(6):612-8
pubmed: 17852800
Clin Chem Lab Med. 2015 Feb;53(3):403-14
pubmed: 25274955
Acta Med Scand. 1985;218(5):499-503
pubmed: 3911736
PLoS One. 2012;7(8):e43572
pubmed: 22916279
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1817-23
pubmed: 22652598
N Engl J Med. 2013 Sep 5;369(10):932-43
pubmed: 24004120
Trends Cardiovasc Med. 2011 Jul;21(5):140-4
pubmed: 22732549
J Vasc Surg. 2015 Feb;61(2):428-35
pubmed: 25441671
Clin Chem Lab Med. 2010 Nov;48(11):1619-21
pubmed: 21034257
Clin Chem. 1994 Oct;40(10):1921-6
pubmed: 7923773
Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1496-506
pubmed: 27365405
Kidney Int. 2017 Mar;91(3):711-719
pubmed: 28017325
BMC Med. 2012 Dec 05;10:157
pubmed: 23216991
J Am Soc Nephrol. 2011 Oct;22(10):1913-22
pubmed: 21903574
J Atheroscler Thromb. 2003;10(3):154-9
pubmed: 14564084