Association of Serum Calcium and Insulin Resistance With Hypertension Risk: A Prospective Population-Based Study.
calcium
hypertension
insulin resistance
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
08 01 2019
08 01 2019
Historique:
entrez:
1
1
2019
pubmed:
1
1
2019
medline:
4
1
2020
Statut:
ppublish
Résumé
Background The temporal sequence between serum calcium and insulin resistance (IR) and their effects on hypertension are unclear. We studied the association between serum calcium and IR, with risk of hypertension events in a longitudinal cohort conducted in China. Methods and Results Data from 8653 subjects aged 20 to 74 years with an average follow-up of 5.3 years were analyzed. Serum calcium, and fasting and 2-hour serum glucose and insulin were measured at baseline and follow-up. Cross-lagged panel and mediation analysis were used to examine the temporal relationship between serum calcium and IR and its impact on hypertension incidence. The conjoint effects of serum calcium and IR at baseline on hypertension at follow-up were observed ( P=0.029 for HOMA_IR [hepatic IR] and P=0.009 for Gutt index [peripheral IR]). The cross-lagged path coefficient (β
Identifiants
pubmed: 30596304
doi: 10.1161/JAHA.118.009585
pmc: PMC6405709
doi:
Substances chimiques
Biomarkers
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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