Rhodium-Catalyzed Annulation of 4-Arylbut-3-yn-1-amines with Internal Alkynes through C-H Functionalization.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
pubmed:
1
1
2019
medline:
1
1
2019
entrez:
1
1
2019
Statut:
ppublish
Résumé
A new, one-step rhodium(III)-catalyzed annulation of 4-arylbut-3-yn-1-amines with internal alkynes through C-H functionalization is reported. This reaction allows the formation of three new chemical bonds, including two C-C bonds and one C-N band, thus selectively assembling various spiro[indene-1,2'-pyrrolidine]s with excellent functional group compatibility, high atom-economy, and step-efficiency.
Identifiants
pubmed: 30596508
doi: 10.1021/acs.orglett.8b03561
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng