Role of domain interactions in the aggregation of full-length immunoglobulin light chains.

Dimerization Escherichia coli Humans Immunoglobulin Light Chains / metabolism Protein Aggregation, Pathological Protein Domains
antibody light-chain domains light-chain amyloidosis protein aggregation proteinopathy solution NMR spectroscopy

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
15 01 2019
Historique:
pubmed: 2 1 2019
medline: 14 3 2019
entrez: 2 1 2019
Statut: ppublish

Résumé

Amyloid light-chain (LC) amyloidosis is a protein misfolding disease in which the aggregation of an overexpressed antibody LC from a clonal plasma cell leads to organ toxicity and patient death if left untreated. While the overall dimeric architecture of LC molecules is established, with each LC composed of variable (V

Identifiants

DOI: 10.1073/pnas.1817538116 PMID: 30598439 PMC: PMC6338840
pubmed: 30598439
pii: 1817538116
doi: 10.1073/pnas.1817538116
pmc: PMC6338840
doi:

Substances chimiques

Immunoglobulin Light Chains 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

854-863

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK046335
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK046335
Pays : United States
Organisme : Canadian Institutes of Health Research
Pays : International

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Enrico Rennella (E)

Department of Molecular Genetics, The University of Toronto, Toronto, ON, Canada M5S 1A8; rennella@pound.med.utoronto.ca gjmorgan@bu.edu jkelly@scripps.edu kay@pound.med.utoronto.ca.
Department of Biochemistry, The University of Toronto, Toronto, ON, Canada M5S 1A8.
Department of Chemistry, The University of Toronto, Toronto, ON, Canada M5S 1A8.

Gareth J Morgan (GJ)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037; rennella@pound.med.utoronto.ca gjmorgan@bu.edu jkelly@scripps.edu kay@pound.med.utoronto.ca.
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
ORCID: 0000-0002-1275-2010

Jeffery W Kelly (JW)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037; rennella@pound.med.utoronto.ca gjmorgan@bu.edu jkelly@scripps.edu kay@pound.med.utoronto.ca.
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.

Lewis E Kay (LE)

Department of Molecular Genetics, The University of Toronto, Toronto, ON, Canada M5S 1A8; rennella@pound.med.utoronto.ca gjmorgan@bu.edu jkelly@scripps.edu kay@pound.med.utoronto.ca.
Department of Biochemistry, The University of Toronto, Toronto, ON, Canada M5S 1A8.
Department of Chemistry, The University of Toronto, Toronto, ON, Canada M5S 1A8.
Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Dimérisation › Role of domain interactions in the aggregation...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Role of domain interactions in the aggregation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of domain interactions in the aggregation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Sous-unités des immunoglobulines › Chaines légères des immunoglobulines › Role of domain interactions in the aggregation...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Agrégation pathologique de protéines › Role of domain interactions in the aggregation...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Role of domain interactions in the aggregation...