Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice.


Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
22 02 2019
Historique:
received: 20 06 2018
revised: 19 12 2018
pubmed: 2 1 2019
medline: 21 5 2019
entrez: 2 1 2019
Statut: ppublish

Résumé

Targeting toxicity associated with β-amyloid (Aβ) misfolding and aggregation is a promising therapeutic strategy for preventing or managing Alzheimer's disease. The BRICHOS domains from human prosurfactant protein C (proSP-C) and integral membrane protein 2B (Bri2) efficiently reduce neurotoxicity associated with Aβ42 fibril formation both

Identifiants

pubmed: 30598503
pii: S0021-9258(20)39361-3
doi: 10.1074/jbc.RA118.004538
pmc: PMC6393622
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Amyloid beta-Peptides 0
Intercellular Signaling Peptides and Proteins 0
Itm2b protein, mouse 0
Membrane Proteins 0
Peptides 0
Pulmonary Surfactant-Associated Protein C 0
Sftpc protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2606-2615

Informations de copyright

© 2019 Tambaro et al.

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Auteurs

Simone Tambaro (S)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Lorena Galan-Acosta (L)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Axel Leppert (A)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Gefei Chen (G)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Henrik Biverstål (H)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Jenny Presto (J)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Per Nilsson (P)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden.

Jan Johansson (J)

From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden janne.johansson@ki.se.

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Classifications MeSH