TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Amino Acid Sequence
Animals
Binding Sites
Humans
Hydrogen-Ion Concentration
Inhibins
/ metabolism
Mice
Models, Molecular
Protein Binding
Protein Domains
Protein Structure, Secondary
Proteoglycans
/ chemistry
Rats
Receptors, Transforming Growth Factor beta
/ chemistry
Substrate Specificity
Transforming Growth Factor beta2
/ chemistry
ILV methyl labeling
betaglycan
cardiac development
cell signaling
cell surface receptor
endocrinology
finger region
nuclear magnetic resonance (NMR)
transforming growth factor β (TGF-B)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
16
08
2018
revised:
04
12
2018
pubmed:
2
1
2019
medline:
7
5
2019
entrez:
2
1
2019
Statut:
ppublish
Résumé
Betaglycan (BG) is a membrane-bound co-receptor of the TGF-β family that selectively binds transforming growth factor-β (TGF-β) isoforms and inhibin A (InhA) to enable temporal-spatial patterns of signaling essential for their functions
Identifiants
pubmed: 30598510
pii: S0021-9258(20)39242-5
doi: 10.1074/jbc.RA118.005210
pmc: PMC6398128
doi:
Substances chimiques
Proteoglycans
0
Receptors, Transforming Growth Factor beta
0
Transforming Growth Factor beta2
0
inhibin A
0
betaglycan
145170-29-2
Inhibins
57285-09-3
Banques de données
PDB
['2TGI', '5TX6', '2R53', '3EVS']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3065-3080Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM058670
Pays : United States
Informations de copyright
© 2019 Henen et al.
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