Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Animals
Annexin A6
/ metabolism
Cell Line, Tumor
Chemokine CCL2
/ metabolism
Doxorubicin
/ therapeutic use
Extracellular Vesicles
/ drug effects
Female
Humans
Lung Neoplasms
/ drug therapy
Mammary Neoplasms, Experimental
/ drug therapy
Mice, Inbred C57BL
Mice, Knockout
Mice, Nude
Mice, Transgenic
Paclitaxel
/ therapeutic use
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
04
09
2016
accepted:
20
11
2018
pubmed:
2
1
2019
medline:
16
4
2019
entrez:
2
1
2019
Statut:
ppublish
Résumé
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on tumour-derived EVs remain unclear. Here we show that two classes of cytotoxic drugs broadly employed in pre-operative (neoadjuvant) breast cancer therapy, taxanes and anthracyclines, elicit tumour-derived EVs with enhanced pro-metastatic capacity. Chemotherapy-elicited EVs are enriched in annexin A6 (ANXA6), a Ca
Identifiants
pubmed: 30598531
doi: 10.1038/s41556-018-0256-3
pii: 10.1038/s41556-018-0256-3
pmc: PMC6525097
mid: EMS80610
doi:
Substances chimiques
Annexin A6
0
Chemokine CCL2
0
Doxorubicin
80168379AG
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
190-202Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001100
Pays : United States
Organisme : Medical Research Council
ID : G1002033
Pays : United Kingdom
Organisme : Swiss National Science Foundation
ID : 165963
Pays : Switzerland
Organisme : Medical Research Council
ID : MR/N022556/1
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P01 CA080124
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208205
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : European Research Council
ID : 725051
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA197943
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197743
Pays : United States
Commentaires et corrections
Type : CommentIn
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