A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.
BODIPY
Green light
Multimodal therapy
Nitric oxide
Photodynamic therapy
Singlet oxygen
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
08
11
2018
revised:
11
12
2018
accepted:
19
12
2018
pubmed:
2
1
2019
medline:
6
2
2020
entrez:
2
1
2019
Statut:
ppublish
Résumé
Combination of photosensitizers (PS) for photodynamic therapy with NO photodonors (NOPD) is opening intriguing horizons towards new and still underexplored multimodal anticancer and antibacterial treatments not based on "conventional" drugs and entirely controlled by light stimuli. In this contribution, we report an intriguing molecular hybrid based on a BODIPY light-harvesting antenna that acts simultaneously as PS and NOPD upon single photon excitation with the highly biocompatible green light. The presented hybrid offers a combination of superior advantages with respect to the other rare cases reported to date, meeting most of the key criteria for both PSs and NOPDs in the same molecular entity such as: (i) capability to generate
Identifiants
pubmed: 30599409
pii: S0045-2068(18)31286-0
doi: 10.1016/j.bioorg.2018.12.027
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Boron Compounds
0
Nitric Oxide Donors
0
Nitrosamines
0
Photosensitizing Agents
0
Singlet Oxygen
17778-80-2
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-22Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.