Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy.
Adult
Anticonvulsants
/ adverse effects
Databases, Factual
/ trends
Epilepsy
/ drug therapy
Female
Health Resources
/ trends
Humans
Infant
Infant, Newborn
Italy
/ epidemiology
Male
Patient Acceptance of Health Care
Perinatal Care
/ methods
Pregnancy
Pregnancy Complications
/ drug therapy
Pregnancy Outcome
/ epidemiology
Prenatal Exposure Delayed Effects
/ chemically induced
Valproic Acid
/ adverse effects
Clinical pharmacology
Congenital malformation
Epilepsy
Pregnancy
Journal
Epilepsy & behavior : E&B
ISSN: 1525-5069
Titre abrégé: Epilepsy Behav
Pays: United States
ID NLM: 100892858
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
06
09
2018
accepted:
22
09
2018
pubmed:
2
1
2019
medline:
26
5
2020
entrez:
2
1
2019
Statut:
ppublish
Résumé
Healthcare administrative databases of Italy's Lombardy Region were analyzed with the aim to assess perinatal outcomes and healthcare resource utilization during the first year of life in infants exposed to antiepileptic drugs (AEDs) during pregnancy. Drug prescriptions dispensed in the 12 months before delivery to women, who delivered between 2005 and 2011, were analyzed. Neonates were classified as cases if exposed to AEDs, and each case was randomly matched to seven controls. No significant differences were observed in the risk of congenital malformations between 526 cases and 3682 controls except for valproic acid (odds ratio (OR): 2.29; 95% confidence interval (CI): 1.24-4.22) where cases were more likely to be small for gestational age (χ
Identifiants
pubmed: 30599457
pii: S1525-5050(18)30707-8
doi: 10.1016/j.yebeh.2018.09.033
pii:
doi:
Substances chimiques
Anticonvulsants
0
Valproic Acid
614OI1Z5WI
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-17Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.