A terpolymeric hydrogel of hyaluronate-hydroxyethyl acrylate-gelatin methacryloyl with tunable properties as biomaterial.
Animals
Biocompatible Materials
/ chemical synthesis
Cattle
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Chondrocytes
/ drug effects
Dexamethasone
/ chemistry
Drug Carriers
/ chemical synthesis
Drug Liberation
Elasticity
Gelatin
/ chemical synthesis
Humans
Hyaluronic Acid
/ chemical synthesis
Hydrogels
/ chemical synthesis
Male
Mice, Inbred C57BL
Polymerization
Polymethacrylic Acids
/ chemical synthesis
Porosity
Serum Albumin, Bovine
/ chemistry
Bovine serum albumin
Dexamethasone
Drug delivery
Human chondrocytes
Hyaluronate
Hydrogel
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
01 Mar 2019
01 Mar 2019
Historique:
received:
06
10
2018
revised:
29
11
2018
accepted:
10
12
2018
entrez:
3
1
2019
pubmed:
3
1
2019
medline:
10
4
2019
Statut:
ppublish
Résumé
Here, we report synthesis of a terpolymeric covalently crosslinked hydrogel of hyaluronate (HA) as biomaterial with elasticity, mechanical properties and cell interactions via conventional free radical polymerization technique. To provide elasticity and mechanical properties, 2-hydroxyethyl acrylate (HEA) was grafted in HA, while to tune cellular interactions, gelatin methacryloyl (GM) was used as crosslinker. The composition and probable structure of the terpolymer (HA-g-pHEA-x-GM) were analysed by FTIR,
Identifiants
pubmed: 30600048
pii: S0144-8617(18)31454-1
doi: 10.1016/j.carbpol.2018.12.020
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Drug Carriers
0
Hydrogels
0
Polymethacrylic Acids
0
Serum Albumin, Bovine
27432CM55Q
Dexamethasone
7S5I7G3JQL
Gelatin
9000-70-8
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
628-639Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.