Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent.
Benzamide
Mycobacterium tuberculosis
Nitrofuran
α, α-Dimethyl
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
27
10
2018
revised:
20
12
2018
accepted:
22
12
2018
pubmed:
3
1
2019
medline:
7
3
2020
entrez:
3
1
2019
Statut:
ppublish
Résumé
The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular activity (MIC = 0.019-0.20 μM) against the Mycobacterium tuberculosis H37Rv strain and low in vitro cytotoxicity (CC
Identifiants
pubmed: 30600207
pii: S0960-894X(18)31001-1
doi: 10.1016/j.bmcl.2018.12.053
pmc: PMC6368976
mid: NIHMS1517707
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Nitrofurans
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
601-606Subventions
Organisme : NIAID NIH HHS
ID : R21 AI111647
Pays : United States
Organisme : NIAID NIH HHS
ID : R33 AI111647
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109713
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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