Transdiagnostic dimensions of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).
Psychosis
biotypes
bipolar disorder with psychosis
general symptom dimensions
schizoaffective disorder
schizophrenia
specific symptom dimensions
transdiagnostic phenotypes
Journal
World psychiatry : official journal of the World Psychiatric Association (WPA)
ISSN: 1723-8617
Titre abrégé: World Psychiatry
Pays: Italy
ID NLM: 101189643
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
3
1
2019
pubmed:
3
1
2019
medline:
3
1
2019
Statut:
ppublish
Résumé
The validity of the classification of non-affective and affective psychoses as distinct entities has been disputed, but, despite calls for alternative approaches to defining psychosis syndromes, there is a dearth of empirical efforts to identify transdiagnostic phenotypes of psychosis. We aimed to investigate the validity and utility of general and specific symptom dimensions of psychosis cutting across schizophrenia, schizoaffective disorder and bipolar I disorder with psychosis. Multidimensional item-response modeling was conducted on symptom ratings of the Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Montgomery-Åsberg Depression Rating Scale in the multicentre Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium, which included 933 patients with a diagnosis of schizophrenia (N=397), schizoaffective disorder (N=224), or bipolar I disorder with psychosis (N=312). A bifactor model with one general symptom dimension, two distinct dimensions of non-affective and affective psychosis, and five specific symptom dimensions of positive, negative, disorganized, manic and depressive symptoms provided the best model fit. There was further evidence on the utility of symptom dimensions for predicting B-SNIP psychosis biotypes with greater accuracy than categorical DSM diagnoses. General, positive, negative and disorganized symptom dimension scores were higher in African American vs. Caucasian patients. Symptom dimensions accurately classified patients into categorical DSM diagnoses. This study provides evidence on the validity and utility of transdiagnostic symptom dimensions of psychosis that transcend traditional diagnostic boundaries of psychotic disorders. Findings further show promising avenues for research at the interface of dimensional psychopathological phenotypes and basic neurobiological dimensions of psychopathology.
Identifiants
pubmed: 30600629
doi: 10.1002/wps.20607
pmc: PMC6313235
doi:
Types de publication
Journal Article
Langues
eng
Pagination
67-76Subventions
Organisme : US National Institute of Mental Health
ID : MH-077851
Organisme : Netherlands Organization for Scientific Research
ID : 451-13-022
Organisme : NIMH NIH HHS
ID : R01 MH103366
Pays : United States
Organisme : US National Institute of Mental Health
ID : MH-078113
Organisme : US National Institute of Mental Health
ID : MH-077945
Organisme : NIMH NIH HHS
ID : K23 MH102656
Pays : United States
Organisme : US National Institute of Mental Health
ID : MH-077862
Organisme : US National Institute of Mental Health
ID : MH-077852
Informations de copyright
© 2019 World Psychiatric Association.
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