Chronology of motor-mediated microtubule streaming.
cell biology
computational biology
computer simulations
cytoskeletal streaming
kinesin
microtubules
molecular motors
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
29
06
2018
accepted:
28
12
2018
pubmed:
3
1
2019
medline:
19
5
2020
entrez:
3
1
2019
Statut:
epublish
Résumé
We introduce a filament-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct processes of varying duration that make up streaming, from microtubule pairs to collective dynamics. The structures found were polarity sorted due to the propulsion of antialigned microtubules. This also gave rise to the formation of large polar-aligned domains, and streaming at the domain boundaries. Correlation functions, mean squared displacements, and velocity distributions reveal a cascade of processes ultimately leading to microtubule streaming and advection, spanning multiple microtubule lengths. The characteristic times for the processes extend over three orders of magnitude from fast single-microtubule processes to slow collective processes. Our approach can be used to directly test the importance of molecular components, such as motors and crosslinking proteins between microtubules, on the collective dynamics at cellular scale.
Identifiants
pubmed: 30601119
doi: 10.7554/eLife.39694
pii: 39694
pmc: PMC6338466
doi:
pii:
Substances chimiques
Kinesins
EC 3.6.4.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : International Helmholtz Research School of Biophysics and Soft Matter
ID : Graduate Student Fellowship
Pays : International
Informations de copyright
© 2019, Ravichandran et al.
Déclaration de conflit d'intérêts
AR, ÖD, MH, GS, GV, TA, GG No competing interests declared
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