Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
22
06
2018
accepted:
15
11
2018
entrez:
4
1
2019
pubmed:
4
1
2019
medline:
14
2
2019
Statut:
epublish
Résumé
The current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid variation affects cellular processes. These effects may manifest as distinct phenotypic differences between individuals or result in the development of disease. Physical interactions between molecules are the linking steps underlying most, if not all, cellular processes. Understanding the effects that sequence variation has on a molecule's interactions is a key step towards connecting mechanistic characterization of nonsynonymous variation to phenotype. We present an open access resource created over 14 years by IMEx database curators, featuring 28,000 annotations describing the effect of small sequence changes on physical protein interactions. We describe how this resource was built, the formats in which the data is provided and offer a descriptive analysis of the data set. The data set is publicly available through the IntAct website and is enhanced with every monthly release.
Identifiants
pubmed: 30602777
doi: 10.1038/s41467-018-07709-6
pii: 10.1038/s41467-018-07709-6
pmc: PMC6315030
doi:
Types de publication
Dataset
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10Subventions
Organisme : British Heart Foundation
ID : RG/13/5/30112
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM080646
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG002273
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123126
Pays : United States
Organisme : NIGMS NIH HHS
ID : U01 GM120953
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103446
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG007822
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG007822
Pays : United States
Investigateurs
J Khadake
(J)
B Meldal
(B)
S Panni
(S)
D Thorneycroft
(D)
K van Roey
(K)
S Abbani
(S)
L Salwinski
(L)
M Pellegrini
(M)
M Iannuccelli
(M)
L Licata
(L)
G Cesareni
(G)
B Roechert
(B)
A Bridge
(A)
M G Ammari
(MG)
F McCarthy
(F)
F Broackes-Carter
(F)
N H Campbell
(NH)
A N Melidoni
(AN)
M Rodriguez-Lopez
(M)
R C Lovering
(RC)
S Jagannathan
(S)
C Chen
(C)
D J Lynn
(DJ)
S Ricard-Blum
(S)
U Mahadevan
(U)
A Raghunath
(A)
Commentaires et corrections
Type : ErratumIn
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