Predictors of ventricular ablation's success: Viability, innervation, or mismatch?
3-Iodobenzylguanidine
Aged
Catheter Ablation
Female
Heart Ventricles
/ diagnostic imaging
Humans
Male
Middle Aged
Myocardial Infarction
/ complications
Organophosphorus Compounds
Organotechnetium Compounds
Predictive Value of Tests
Radiopharmaceuticals
Retrospective Studies
Tachycardia, Ventricular
/ diagnostic imaging
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Intervention tracers
cardiac innervation
diagnostic and prognostic application
image-guided application
multimodality
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
02
10
2018
accepted:
07
12
2018
pubmed:
4
1
2019
medline:
15
12
2021
entrez:
4
1
2019
Statut:
ppublish
Résumé
Sympathetic dys-innervation may play an important role in the development of post-ischemic ventricular arrhythmias (VA). Aim of this study was to prove that perfusion/innervation mismatch (PIM) evaluated by SPECT can identify areas of local abnormal ventricular activities (LAVA) on electroanatomic mapping (EAM). Sixteen patients referred to post-ischemic VA catheter ablation underwent pre-procedural and 1-month post-ablation Before ablation, the mean voltage in the PIM segments was higher than in the scarred ones but lower than in the normal regions. The presence of PIM in a specific LV zone was an independent predictor of LAVA. After ablation, PIM value was significantly reduced, mainly due to an increase in perfusion summed rest score, in particular in patients that were responders to ablation. PIM may associate with VA substrate expressed by LAVA and might provide a novel guide for substrate ablation. A significant reduction of PIM could predict a positive clinical response to ablation.
Identifiants
pubmed: 30603891
doi: 10.1007/s12350-018-01575-x
pii: 10.1007/s12350-018-01575-x
doi:
Substances chimiques
Organophosphorus Compounds
0
Organotechnetium Compounds
0
Radiopharmaceuticals
0
3-Iodobenzylguanidine
35MRW7B4AD
technetium tc-99m tetrofosmin
42FOP1YX93
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-183Commentaires et corrections
Type : CommentIn
Références
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