How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network.
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Donor Selection
Female
Humans
Italy
Male
Middle Aged
Neoplasms
/ complications
Organ Transplantation
/ adverse effects
Patient Safety
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Tissue Donors
/ supply & distribution
Treatment Outcome
Young Adult
Donor evaluation
Donor with malignancy
Neoplastic transmission
Risk assessment
Transplantation
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
15
10
2018
accepted:
17
12
2018
pubmed:
4
1
2019
medline:
28
4
2020
entrez:
4
1
2019
Statut:
ppublish
Résumé
Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Donors with neoplasia represented about 5% of all donors, resulting in about 4% of all transplants. Donors presented a benign neoplasm in 29.08% of cases, a malignancy with variable risk of transmission in 69.75% while in 1.34% the nature of neoplasm could not be assessed. Considering all procedures, rate of transmission of a malignancy was 0.03% (10 cases) of all 29858 transplants of the time interval. Notably, cases of transmission were not from donors of this pool, but from donors that, according to our protocols, had no elements of suspect at time of donation. As recipient safety is always the priority and as guidelines have set exclusion criteria for donors with some specific types of malignancy, these results show that use of this type of donors is safe and improve organ pool. Furthermore represent basis for improvement and standardization of donor assessment protocols suggesting that efforts in data collection systems, to produce complete and homogeneous data, are mandatory.
Identifiants
pubmed: 30604151
doi: 10.1007/s40620-018-00573-z
pii: 10.1007/s40620-018-00573-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
323-330Références
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