A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions.
Animals
Antibody-Dependent Cell Cytotoxicity
Antigens, CD
/ immunology
Antineoplastic Agents, Immunological
/ immunology
CHO Cells
Cricetulus
HEK293 Cells
Humans
Leukemia, Erythroblastic, Acute
/ drug therapy
Lymphoma, B-Cell
/ drug therapy
Mice
Mice, Knockout
Receptors, Transferrin
/ immunology
Single-Chain Antibodies
/ immunology
Transferrin receptor 1
iron metabolism
leukemia
therapeutic antibody
Journal
mAbs
ISSN: 1942-0870
Titre abrégé: MAbs
Pays: United States
ID NLM: 101479829
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
4
1
2019
medline:
9
8
2019
entrez:
4
1
2019
Statut:
ppublish
Résumé
Targeting transferrin receptor 1 (TfR1) with monoclonal antibodies is a promising therapeutic strategy in cancer as tumor cells often overexpress TfR1 and show increased iron needs. We have re-engineered six anti-human TfR1 single-chain variable fragment (scFv) antibodies into fully human scFv
Identifiants
pubmed: 30604643
doi: 10.1080/19420862.2018.1564510
pmc: PMC6512944
doi:
Substances chimiques
Antigens, CD
0
Antineoplastic Agents, Immunological
0
CD71 antigen
0
Receptors, Transferrin
0
Single-Chain Antibodies
0
Tfrc protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
593-605Références
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