Myocardin Is Involved in Mesothelial-Mesenchymal Transition of Human Pleural Mesothelial Cells.
Active Transport, Cell Nucleus
/ drug effects
Adult
Aged
Aged, 80 and over
Animals
Bleomycin
/ adverse effects
Cell Nucleus
/ metabolism
Disease Models, Animal
Empyema, Pleural
/ chemically induced
Female
Fibrosis
Humans
Male
Mice
Middle Aged
Myofibroblasts
/ metabolism
Nuclear Proteins
/ metabolism
Pleura
/ metabolism
Soot
/ toxicity
Trans-Activators
/ metabolism
Transforming Growth Factor beta
/ metabolism
mesothelial–mesenchymal transition
myocardin
pleural fibrosis
smooth muscle
α-smooth muscle actin
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
4
1
2019
medline:
13
2
2020
entrez:
4
1
2019
Statut:
ppublish
Résumé
Pleural fibrosis is characterized by severe inflammation of the pleural space and pleural reorganization. Subsequent thickening of the visceral pleura contributes to lung stiffness and impaired lung function. Pleural mesothelial cells (PMCs) can become myofibroblasts
Identifiants
pubmed: 30605348
doi: 10.1165/rcmb.2018-0121OC
pmc: PMC6604219
doi:
Substances chimiques
Nuclear Proteins
0
Soot
0
Trans-Activators
0
Transforming Growth Factor beta
0
myocardin
0
Bleomycin
11056-06-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-96Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL115466
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111696
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130133
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142853
Pays : United States
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