Activation of the hypothalamic paraventricular nucleus by acute intermittent hypoxia: Implications for sympathetic long-term facilitation neuroplasticity.


Journal

Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712

Informations de publication

Date de publication:
04 2019
Historique:
received: 15 09 2018
revised: 03 12 2018
accepted: 30 12 2018
pubmed: 4 1 2019
medline: 23 2 2020
entrez: 4 1 2019
Statut: ppublish

Résumé

Exposure to acute intermittent hypoxia (AIH) induces a progressive increase of sympathetic nerve activity (SNA) that reflects a form of neuroplasticity known as sympathetic long-term facilitation (sLTF). Our recent findings indicate that activity of neurons in the hypothalamic paraventricular nucleus (PVN) contributes to AIH-induced sLTF, but neither the intra-PVN distribution nor the neurochemical identity of AIH responsive neurons has been determined. Here, awake rats were exposed to 10 cycles of AIH and c-Fos immunohistochemistry was performed to identify transcriptionally activated neurons in rostral, middle and caudal planes of the PVN. Effects of graded intensities of AIH were investigated in separate groups of rats (n = 6/group) in which inspired oxygen (O

Identifiants

pubmed: 30605624
pii: S0014-4886(18)30481-3
doi: 10.1016/j.expneurol.2018.12.011
pmc: PMC6378125
mid: NIHMS1518209
pii:
doi:

Substances chimiques

Neuropeptides 0
Proto-Oncogene Proteins c-fos 0
Arginine Vasopressin 113-79-1
Corticotropin-Releasing Hormone 9015-71-8

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL088052
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007446
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Nadia Oliveira Maruyama (NO)

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Nathan C Mitchell (NC)

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Tamara T Truong (TT)

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Glenn M Toney (GM)

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: toney@uthscsa.edu.

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Classifications MeSH