The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer.
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Titre abrégé: Biochim Biophys Acta Gene Regul Mech
Pays: Netherlands
ID NLM: 101731723
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
09
11
2018
revised:
20
12
2018
accepted:
20
12
2018
pubmed:
4
1
2019
medline:
26
7
2019
entrez:
4
1
2019
Statut:
ppublish
Résumé
A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.
Identifiants
pubmed: 30605729
pii: S1874-9399(18)30478-4
doi: 10.1016/j.bbagrm.2018.12.007
pii:
doi:
Substances chimiques
MicroRNAs
0
Inosine
5A614L51CT
Adenosine Deaminase
EC 3.5.4.4
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
291-300Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.