Advanced drug delivery systems and artificial skin grafts for skin wound healing.
Scaffold
Skin substitute
Wound healing
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
10
08
2018
revised:
27
11
2018
accepted:
27
12
2018
pubmed:
4
1
2019
medline:
30
7
2020
entrez:
4
1
2019
Statut:
ppublish
Résumé
Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require painstakingly long-term treatment with an immense financial burden to healthcare systems worldwide. However, clinical management of chronic wounds remains unsatisfactory in many cases. Various strategies including growth factor and gene delivery as well as cell therapy have been used to enhance the healing of non-healing wounds. Drug delivery systems across the nano, micro, and macroscales can extend half-life, improve bioavailability, optimize pharmacokinetics, and decrease dosing frequency of drugs and genes. Replacement of the damaged skin tissue with substitutes comprising cell-laden scaffold can also restore the barrier and regulatory functions of skin at the wound site. This review covers comprehensively the advanced treatment strategies to improve the quality of wound healing.
Identifiants
pubmed: 30605737
pii: S0169-409X(18)30318-1
doi: 10.1016/j.addr.2018.12.014
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-239Informations de copyright
Copyright © 2018. Published by Elsevier B.V.