Derivation of iPSC lines from two patients with familial Alzheimer's disease from India.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
13
10
2018
revised:
05
12
2018
accepted:
15
12
2018
pubmed:
4
1
2019
medline:
7
8
2019
entrez:
4
1
2019
Statut:
ppublish
Résumé
The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.
Identifiants
pubmed: 30605839
pii: S1873-5061(18)30305-2
doi: 10.1016/j.scr.2018.101370
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
101370Informations de copyright
Copyright © 2018. Published by Elsevier B.V.