In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors.
Enzyme inhibitor activity
MAO inhibitors
Molecular docking
Thiazole derivatives
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
24
10
2018
revised:
11
12
2018
accepted:
12
12
2018
pubmed:
4
1
2019
medline:
12
2
2020
entrez:
4
1
2019
Statut:
ppublish
Résumé
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized compounds. Most of them showed remarkable inhibitory activity against both MAO-A and MAO-B. By comparing their IC
Identifiants
pubmed: 30605888
pii: S0045-2068(18)31217-3
doi: 10.1016/j.bioorg.2018.12.019
pii:
doi:
Substances chimiques
Monoamine Oxidase Inhibitors
0
Thiazoles
0
Monoamine Oxidase
EC 1.4.3.4
monoamine oxidase A, human
EC 1.4.3.4.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-108Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.