Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.

Adipose Tissue / physiopathology Animals Cell Culture Techniques Humans Male Mice Obesity / complications Oxidative Stress Prostatic Neoplasms / etiology Transfection

Journal

Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042

Informations de publication

Date de publication:
03 2019
Historique:
received: 23 07 2018
revised: 02 10 2018
accepted: 19 12 2018
pubmed: 5 1 2019
medline: 25 1 2020
entrez: 5 1 2019
Statut: ppublish

Résumé

Prostate gland is surrounded by periprostatic adipose tissue (PPAT), which is increasingly believed to play a paracrine role in prostate cancer progression. Our previous work demonstrates that adipocytes promote homing of prostate cancer cells to PPAT and that this effect is upregulated by obesity. Here, we show that once tumor cells have invaded PPAT (mimicked by an

Identifiants

DOI: 10.1158/1541-7786.MCR-18-0748 PMID: 30606769
pubmed: 30606769
pii: 1541-7786.MCR-18-0748
doi: 10.1158/1541-7786.MCR-18-0748
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

821-835

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Victor Laurent (V)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Aurélie Toulet (A)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Camille Attané (C)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Delphine Milhas (D)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Stéphanie Dauvillier (S)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Falek Zaidi (F)

Service d'Anatomo-Pathologie, Institut Universitaire du Cancer, Toulouse, France.

Emily Clement (E)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Mathieu Cinato (M)

Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université de Toulouse, Inserm UMR 1048, UPS, Toulouse, France.

Sophie Le Gonidec (S)

Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université de Toulouse, Inserm UMR 1048, UPS, Toulouse, France.

Adrien Guérard (A)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Camille Lehuédé (C)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

David Garandeau (D)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Laurence Nieto (L)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Edith Renaud-Gabardos (E)

Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université de Toulouse, Inserm UMR 1048, UPS, Toulouse, France.

Anne-Catherine Prats (AC)

Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université de Toulouse, Inserm UMR 1048, UPS, Toulouse, France.

Philippe Valet (P)

Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université de Toulouse, Inserm UMR 1048, UPS, Toulouse, France.

Bernard Malavaud (B)

Département d'Urologie, Institut Universitaire du Cancer, Toulouse, France.

Catherine Muller (C)

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France. muller@ipbs.fr.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Periprostatic Adipose Tissue Favors Prostate...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › Periprostatic Adipose Tissue Favors Prostate...