Lipid Peroxidation Drives Renal Cyst Growth
Animals
Anoctamin-1
/ genetics
Biopsy, Needle
Cell Proliferation
/ drug effects
Cells, Cultured
Humans
Immunohistochemistry
In Vitro Techniques
Lipid Peroxidation
/ physiology
Mice
Oxidative Stress
Polycystic Kidney, Autosomal Dominant
/ metabolism
Reactive Oxygen Species
/ metabolism
Sensitivity and Specificity
ADPKD
TMEM16A
anoctamin 1
ferroptosis
lipid peroxidation
reactive oxygen species
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
01
2018
accepted:
19
11
2018
pubmed:
5
1
2019
medline:
5
11
2019
entrez:
5
1
2019
Statut:
ppublish
Résumé
Transepithelial chloride Using tissue samples from patients with autosomal dominant PKD, embryonic kidney cultures, and an MDCK Peroxidation of phospholipids in human and mouse kidneys as well as MDCK cysts These findings indicate that activation of TMEM16A by lipid peroxidation drives growth of renal cysts. We propose direct inhibition of TMEM16A or inhibition of lipid peroxidation as potentially powerful therapeutic approaches to delay cyst development in PKD.
Sections du résumé
BACKGROUND
Transepithelial chloride
METHODS
Using tissue samples from patients with autosomal dominant PKD, embryonic kidney cultures, and an MDCK
RESULTS
Peroxidation of phospholipids in human and mouse kidneys as well as MDCK cysts
CONCLUSIONS
These findings indicate that activation of TMEM16A by lipid peroxidation drives growth of renal cysts. We propose direct inhibition of TMEM16A or inhibition of lipid peroxidation as potentially powerful therapeutic approaches to delay cyst development in PKD.
Identifiants
pubmed: 30606785
pii: ASN.2018010039
doi: 10.1681/ASN.2018010039
pmc: PMC6362630
doi:
Substances chimiques
Anoctamin-1
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-242Informations de copyright
Copyright © 2019 by the American Society of Nephrology.
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